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Modulyo - designing a freeze drying system

MicroModulyo 1.5 litre Freeze Dryer

ModulyoD 5 litre Freeze Dryer

SuperModulyo 20 litre Freeze Dryer

Modulyo column and drum manifolds

Modulyo flasks, lids and adapters

Modulyo tray cells and drying tray kits

Modulyo temperature control and isolation valve

Modulyo vial cell stoppering shelf

Modulyo spin freezers and secondary manifolds

Modulyo specimen drying

Modulyo pumps and accessories



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Modulyo
Designing Your Freeze Drying System


Answer these key questions to successfully design your Modulyo freeze drying system.

Will this freeze dryer be used for a single application or multiple
applications?

Consider not only the primary application, but also other, less frequently performed applications, for your freeze drying system. For example, flask drying may be successfully performed using a column manifold, but if loose material will also be dried, a drum manifold, with its large internal cavity that accommodates shallow trays, might be a better choice.

What type of sample containers will you use with your freeze drying system?

Will your sample be dried in flasks, vials or ampules, or will it be loose material that requires shallow trays? The type and number of sample containers will dictate not only the type of drying accessory, but also the size of the ice condenser module. Loose material in large shallow trays requires both a larger ice condenser and a larger drying accessory than samples dried in 2 ml glass ampules or 10 ml vials.

What is the total volume of ice to be extracted at one time?

Ice condensers are rated by the maximum volume of ice they can hold before they need to be shut down and emptied. Routinely drying 300 ml of frozen sample in two 1 liter flasks would easily be accommodated by the 1.5 liter MicroModulyo. Drying sample material in twenty, 1 liter flasks that are each half full would require the ice capacity of the SuperModulyo.

What is the minimum pump displacement capacity required to operate the freeze drying system?

In order to keep the sample frozen during the entire freeze drying process it must be kept under constant vacuum. Column manifolds used on a MicroModulyo have a small internal volume and therefore do not require a large capacity pump. Some freeze drying systems however, such as those that are used to dry bulk material in trays, have larger internal volumes and require a larger capacity pump to evacuate the total internal volume before the sample begins to thaw.

What is the maximum temperature at which all of the solvent can be successfully trapped before it
reaches the vacuum pump?
Modulyo ice condensers operate at a nominal temperature of -50 °C. This is more than cold enough for the vast majority of freeze drying applications. Some applications, however, will require lower temperatures to protect the pump. For these applications, Thermo Electron offers a temperature trap to supplement the Modulyo ice condensers.

modulyo-freeze-drying